Enrichment analysis in genome-wide gene studies is essential to find biological functions that are particularly abundant in a group of genes more than would be expected by chance.

Here we provide the enrichment analysis tool to find out whether a target gene list is enriched in any of the predefined ecDNA gene sets. Overrepresentation analysis (ORA) and gene set enrichment analysis (GSEA) are two predominant methods, and they have been integrated into this tool.

ORA tests whether a gene set is overrepresented in an experimentally-derived gene list. GSEA tests whether genes of a gene set accumulate at the top or bottom of the full gene vector ordered by a specific metric, such as direction and magnitude of expression change.